{"id":4279,"date":"2020-04-14T08:00:37","date_gmt":"2020-04-14T12:00:37","guid":{"rendered":"http:\/\/impulse-dynamics-multisite.flywheelsites.com\/ous\/?p=4279"},"modified":"2024-01-17T04:28:34","modified_gmt":"2024-01-17T09:28:34","slug":"impulse-dynamics-announces-publication-of-data-from-fix-hf-5c2-study-evaluating-the-two-lead-optimizer-system","status":"publish","type":"post","link":"https:\/\/impulse-dynamics.com\/global\/impulse-dynamics-announces-publication-of-data-from-fix-hf-5c2-study-evaluating-the-two-lead-optimizer-system\/","title":{"rendered":"Impulse Dynamics Announces Publication of Data from FIX-HF-5C2 Study Evaluating the Two-Lead Optimizer System"},"content":{"rendered":"

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NEWS<\/h2>\n

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Impulse Dynamics Announces Publication of Data from FIX-HF-5C2 Study Evaluating the Two-Lead Optimizer System<\/h4>\n

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Availability of the two-lead device represents a significant advancement in the development of cardiac contractility modulation therapy for patients with heart failure<\/em><\/h3>\n

MT. LAUREL, N.J.\u2013 April 14, 2020<\/strong> \u2013 Impulse Dynamics, a medical device company dedicated to improving the lives of heart failure patients, today announced the publication of the FIX-HF-5C2 study in Circulation: Heart Failure<\/a>. The study affirms the safety and efficacy of the company\u2019s 2-lead version of the Optimizer\u00ae system, which was approved by the FDA in October 2019.<\/p>\n

The prospective, multicenter, single-arm study was designed to evaluate the performance, safety and efficacy of the 2-lead Optimizer system. The study confirmed the 2-lead version of the device is just as effective at delivering CCM\u2122 (cardiac contractility modulation) therapy as the 3-lead version and by eliminating the atrial lead, patients experienced significantly fewer device-related complications when compared to the 3-lead version. Patients that received the 2-lead version had a significantly greater improvement in exercise capacity (as measured by peak VO2) and functional status (as measured by New York Heart Association functional class) when compared to the FIX-HF-5C control group. Additionally, 15% of the patients enrolled in the FIX-HF-5C2 study had atrial fibrillation.<\/p>\n

\u201cThe publication of this data confirms that the 2-lead device is a significant advancement for how we can provide CCM therapy to heart failure patients,\u201d said Ishu Rao, M.D., Medical Director for Impulse Dynamics. \u201cNotably, the data shows that CCM therapy has a substantial positive impact on a patient\u2019s functional capacity over time versus standard medical care alone. There has been tremendous excitement from patients and providers for the 2-lead Optimizer system and we look forward to continuing to expand the adoption of this breakthrough treatment option.\u201d<\/p>\n

The FIX-HF-5C2 study was a confirmatory extension of the FIX-HF-5C randomized study and enrolled heart failure patients from eight medical centers in the U.S. and Germany. Patients were evaluated at baseline and again at 12 and 24 weeks after implantation.<\/p>\n

\u201cThe 2-lead version of the Optimizer system is an important evolution that reduces lead-related complications and simplifies the implantation procedure,\u201d said Phi Wiegn, M.D., of the Dallas VA Medical Center and lead author of the publication. \u201cCCM is a truly unique device therapy that I can offer to a large group of heart failure patients to make them feel better when standard medical therapy no longer does.\u201d<\/p>\n

CCM therapy may be an appropriate treatment option for the approximately 70 percent of NYHA Class III heart failure patients who remain symptomatic despite guideline-directed medical therapy..1<\/sup> <\/span><\/p>\n

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\nAbout the Optimizer and CCMTM<\/sup><\/span>\u00a0Therapy
\n<\/strong>CCM therapy, delivered by the Optimizer system, is a breakthrough approach for treating heart failure that is proven to improve quality of life for suitable patients.1<\/sup> <\/span> The innovative therapy is the first therapy of its kind designed to improve contraction of the heart, allowing more oxygen-rich blood to reach the body.1<\/sup> <\/span>CCM therapy delivers precisely timed electrical pulses to the heart during the absolute refractory period of the beating cycle, just after the heart contracts. The Optimizer system was granted Breakthrough Device designation by the FDA and is the first and only FDA-approved device in the U.S. or elsewhere for the delivery of CCM therapy.<\/p>\n

 <\/p>\n

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About Heart Failure
<\/strong>Heart failure, a condition in which the heart slowly weakens and is not able to adequately supply oxygen-rich blood, affects an estimated 6.5 million Americans and nearly 26 million people worldwide.2<\/sup> <\/span>\u00a0By 2030, it is expected to affect 8 million Americans.3<\/sup> <\/span>Heart failure patients experience debilitating symptoms, including breathlessness, fatigue, confusion and swelling in the legs that make everyday activities challenging and significantly diminish their quality of life. Nearly 50 percent of people with heart failure die within five years of being diagnosed.3<\/sup> <\/span>\u00a0The annual cost for healthcare services, medications and lost working days in the US is estimated to reach $70 billion by 2030.3<\/sup> <\/span><\/p>\n

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About Impulse Dynamics
<\/strong>Impulse Dynamics, based in Mount Laurel, N.J., is dedicated to improving the lives of people with heart failure by transforming how the condition is treated. The company has pioneered CCM TM<\/sup> <\/span>\u00a0therapy (cardiac contractility modulation), which is delivered by the company\u2019s Optimizer\u00ae<\/sup> <\/span>system, a breakthrough, FDA-approved treatment that is proven to improve the quality of life for heart failure patients.1<\/sup> <\/span>\u00a0CCM therapy is a safe and effective minimally invasive treatment option for many heart failure patients who otherwise have few effective options available to them.1<\/sup> <\/span>\u00a0To learn more visit\u00a0www.impulse-dynamics.com, or follow the company on\u00a0LinkedIn<\/a>\u00a0and\u00a0Twitter<\/a>.<\/p>\n

[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section][et_pb_section fb_built=”1″ _builder_version=”3.22″ custom_padding=”0px|||||”][et_pb_row _builder_version=”3.25″ background_size=”initial” background_position=”top_left” background_repeat=”repeat” custom_padding=”0px|||||”][et_pb_column type=”4_4″ _builder_version=”3.0.47″ custom_padding=”|||” custom_padding__hover=”|||”][et_pb_text _builder_version=”4.0.6″ z_index_tablet=”500″ text_text_shadow_horizontal_length_tablet=”0px” text_text_shadow_vertical_length_tablet=”0px” text_text_shadow_blur_strength_tablet=”1px” link_text_shadow_horizontal_length_tablet=”0px” link_text_shadow_vertical_length_tablet=”0px” link_text_shadow_blur_strength_tablet=”1px” ul_text_shadow_horizontal_length_tablet=”0px” ul_text_shadow_vertical_length_tablet=”0px” ul_text_shadow_blur_strength_tablet=”1px” ol_text_shadow_horizontal_length_tablet=”0px” ol_text_shadow_vertical_length_tablet=”0px” ol_text_shadow_blur_strength_tablet=”1px” quote_text_shadow_horizontal_length_tablet=”0px” quote_text_shadow_vertical_length_tablet=”0px” quote_text_shadow_blur_strength_tablet=”1px” header_text_shadow_horizontal_length_tablet=”0px” header_text_shadow_vertical_length_tablet=”0px” header_text_shadow_blur_strength_tablet=”1px” header_2_text_shadow_horizontal_length_tablet=”0px” header_2_text_shadow_vertical_length_tablet=”0px” header_2_text_shadow_blur_strength_tablet=”1px” header_3_text_shadow_horizontal_length_tablet=”0px” header_3_text_shadow_vertical_length_tablet=”0px” header_3_text_shadow_blur_strength_tablet=”1px” header_4_text_shadow_horizontal_length_tablet=”0px” header_4_text_shadow_vertical_length_tablet=”0px” header_4_text_shadow_blur_strength_tablet=”1px” header_5_text_shadow_horizontal_length_tablet=”0px” header_5_text_shadow_vertical_length_tablet=”0px” header_5_text_shadow_blur_strength_tablet=”1px” header_6_text_shadow_horizontal_length_tablet=”0px” header_6_text_shadow_vertical_length_tablet=”0px” header_6_text_shadow_blur_strength_tablet=”1px” box_shadow_horizontal_tablet=”0px” box_shadow_vertical_tablet=”0px” box_shadow_blur_tablet=”40px” box_shadow_spread_tablet=”0px”]<\/p>\n

References<\/strong><\/p>\n

1<\/sup>Abraham WT, Kuck KH, Goldsmith RL, et al. A randomized controlled trial to evaluate the safety and efficacy of cardiac contractility modulation<\/a>. JACC Heart Failure. 6(10), 874-883 (2018).<\/p>\n

2<\/sup>Savarese G, Lund LH. Global Public Health Burden of Heart Failure<\/a>. Card Fail Rev. 2017 Apr; 3(1): 7\u201311.<\/p>\n

3<\/sup>Benjamin E, Blaha M, Chiuve S, et al. Heart Disease and Stroke Statistics\u20142017 Update: A Report From the American Heart Association<\/a>. Circulation. 2017;135:e146\u2013e603<\/p>\n

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